Abstract Herein we report the synthesis and activity of an enzyme‐directed immunostimulant with immune cell activation mediated by β‐galactosidase, either exogenously added, or on B16 melanoma cells. Covalent attachment of…

Abstract We have recently developed an enzyme-directed immunostimulant (EDI) prodrug motif, which is metabolized to active immunostimulant by cancer cells and, following drug efflux, activates nearby immune cells, resulting in…

Abstract Drug efflux and enzymatic drug degradation are two cellular mechanisms that contribute to drug resistance in many cancers. Herein, we report the synthesis and in vitro activity of a…